analytical-method-validation
No security findings. Scanned 1 time, most recently 2026-10-21.
Second scanner: NVIDIA SkillSpector
Independent static run, no language model, over the same files as the Cisco scan above. How the two scanners compare across the whole corpus: Two scanners, one corpus.
What this skill does
Plans, executes, and documents validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV", "validation protocol", "acceptance criteria", "linearity", "reportable range", "accuracy and precision",…
- Package
- 17 files, 219 KB
- SKILL.md
- 2570 words, 12+ sections
- Code
- Python (8)
- Allowed tools
ReadWriteEditBash- License
- MIT
- Compatibility
- Requires Python 3.11+. Scripts use only the standard library - no numpy, scipy, or network access. Statistical distributions are computed from first principles so results are reproducible in any conforming interpreter.
SKILL.md covers: Analytical Method Validation · When to use · The two rules · Scope · Copyright boundary · Frameworks · Scripts · Workflow · 1. Fix the framework and the required characteristics · 2. Generate the protocol and fill in the criteria · 3. Evaluate the response · 4. Evaluate accuracy and precision
Findings
No findings. SAFE
What is in the package
| File | Kind | Size |
|---|---|---|
SKILL.md | doc | 19 KB |
assets/validation-protocol-template.md | doc | 4.1 KB |
assets/validation-report-template.md | doc | 3.9 KB |
references/compendial-and-clsi.md | doc | 7.6 KB |
references/framework-selection.md | doc | 5.3 KB |
references/ich-m10-bioanalytical.md | doc | 8.8 KB |
references/ich-q2r2.md | doc | 13 KB |
references/source-ledger.md | doc | 7.5 KB |
references/statistics.md | doc | 13 KB |
scripts/_catalog.py | script | 23 KB |
scripts/_common.py | script | 34 KB |
scripts/check_accuracy_precision.py | script | 16 KB |
scripts/check_bioanalytical_run.py | script | 14 KB |
scripts/check_detection_limits.py | script | 14 KB |
scripts/check_response.py | script | 10 KB |
scripts/compare_methods.py | script | 9.1 KB |
scripts/plan_validation.py | script | 15 KB |
External hosts referenced
clsi.org database.ich.org doi.usp.org www.cms.gov www.iso.org arxiv.org www.itl.nist.gov www.uspnf.com doi.org export.arxiv.org itl.nist.gov www.ema.europa.eu www.usp.org
Hostnames that appear in the skill's files. Referencing a host is not a finding; compare against the findings above and the skill's stated purpose.
Package contents recorded 2026-10-22 at commit 593377bb0487. The scan above ran against the version current at scan time; the two can differ if the skill has since been updated.
What we checked
- Static analyzer. Pattern rules over SKILL.md and bundled files: known-bad commands, exfiltration URLs, secrets, obfuscation.
- Bytecode analyzer.
- Pipeline analyzer.
- Correlation analyzer.
- Behavioral analyzer. Checks what the skill asks the agent to do against what its description claims it does.
- Trigger analyzer. Looks for instructions that fire on conditions the user did not ask for.
What we did not check
- Runtime behaviour. The skill was not executed; findings come from reading its files.
- Anything fetched at install or run time, including remote scripts, package dependencies, and URLs the skill tells the agent to open.
- Content the analyzers cannot read: images, binaries, and some non-English text.
- Known scanner bypass classes. See the methodology and limitations page.
Sources
- Repository: https://github.com/K-Dense-AI/scientific-agent-skills
- Raw scan result: skills-analytical-method-validation-scan.json
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